A serial killer that admires the infamous Zodiac Killer prowls New York City's streets for six years, trying to kill one person for every zodiac sign. Police use a variety of forensic tools to arrest the culprit.
When one woman's drowning death in Pennsylvania triggers another investigation into a woman's eerily similar death in North Carolina, medical examiners must determine if the women drowned or were in fact murdered.
A couple was murdered during what looked like a drug deal gone awry. But police found no drugs in the home of the victims and there were no traces of the victims' blood on the clothing of the suspects. The victim's dog eventually led police to the killer.
Years after a man is hailed for shooting the man who allegedly criminally harassed him and murdered his wife after breaking into their home, new technologies force the police to reassess the case. A tragic tale soon becomes even more tragic in a new way.