A police recruit named a hero after breaking up a bodega robbery is found murdered soon after. Detectives Logan and Wheeler initially suspect it had something to do with the recruit's heroism, but discover his girlfriend has suddenly gone missing.
A police officer is shot in the line of duty and detectives race to the scene. Eames recognizes the victim: her husband's partner from the night he was murdered. Eames is forced to reinvestigate her husband's murder to solve the current murder case.
A Park Avenue dentist's murder turns out to be connected to the death of one of his young patients. As detectives look into both deaths, they follow a trail of counterfeit and poisoned mouthwash from the streets of Harlem to the FDA and Wall Street.
The Replicator returns to target a member of the BAU. Meanwhile, Hotch's estranged brother is caught in the middle of the team's investigation into a string of deaths in Manhattan tied to apparent ecstasy overdose.