Zoe Hart, a fast-talking New Yorker and brand new doctor, thought she had it all figured out and was going to follow in her father's footsteps to be a heart surgeon. When her dream plans fail, she accepts a job from a stranger to work as a general practitioner in a small town in Alabama called Bluebell. Zoe (Rachel Bilson) arrives to find that the doctor she made the deal with, Dr. Harley Wilkes, has passed away and left his half of the practice to her in his will. Zoe makes some new friends who have taken the Southern hospitality to heart, along with some new enemies, and discovers a side of herself that she didn't know was there in this small-town life.
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