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A man uses his extraordinary talent for unconventional problem solving to save lives.
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Mac and Jack help Mac's close friend from M.I.T. after she fakes her own death. They must unravel the truth as she runs for her life from those trying to supress her scientific research.
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Angus 'Mac' MacGyver and Jack Dalton join forces to recover a mission bioweapon that has the ability to destroy hundreds of thousands of people with one single drop.