Born into a family of demon hunters, two Winchester brothers; Sam (Jared Padalecki) and Dean (Jensen Ackles) drive across country to solve supernatural murders. These siblings are highly trained in killing poltergeists, demons, ghosts, and any evil monsters they may come across. Throughout the years the brothers have saved Earth and the plight of humanity from apocalyptic evil. They have had the minions of the Devil against them, and the angels from the hand of God to help them. The Earth is a secret battle field between good and evil, and the Winchester brothers are caught in the middle, fighting to stay alive.
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After Dean tells Sam what their father said before he died, Sam sneaks off to Indiana without him. While there, Sam runs into Eva, a psychic. Dean discovers Gordon is after Sam and races to find his brother in time to save him.