The Halliwell sisters' long lost father unexpectedly turns up and has intentions of getting the Book of Shadows out of their house; simultaneously, mysterious new neighbors move in across the street with intentions of their own.
Sam has flashbacks to a case he worked on with Samuel before he reconnected with Dean. When Sam receives a mysterious text with coordinates to a small town, the brothers investigate. Dean is surprised to learn that the townspeople seem to know Sam.
Ben calls Dean and tells him Lisa is in trouble. Dean leaves Sam to investigate a case and rushes home to rescue Lisa, but he's not prepared for what meets him at the door. Meanwhile, Sam discovers a cruel joke played on a woman who went missing.
Raphael sends a particularly frightening angelic hit man after Balthazar, Sam and Dean. To protect the brothers, Balthazar sends them to an alternate universe where they are actors named Jensen Ackles and Jared Padalecki on a show called 'Supernatural.'
Sam, Dean and Bobby search for The Mother of All's latest monster. While investigating, they run into Samuel and Gwen, who are also hunting the creature. Samuel and Bobby get into a heated argument about how to handle the case.
The team investigates the murder of Lauren Frank, a kidnapping victim whose remains were found buried at a park. When they discover the unhappy relationship that Lauren had with her stepmother, the team starts to think the killer could be someone closer.
When a CIA informant is found murdered, Booth and CIA Agent Danny Beck must work together to track down an Afghani terrorist. Brennan wants to work more closely with Booth in the field, and the duo must confront the implications of what that means.
A repo man's remains are found in a septic tank, and the Jeffersonian team must work together to figure out who the killer is. When the team discovers that the victim had a troubled past, some key witnesses from his earlier days become potential suspects.
When a wealthy artifact collector walks into his own funeral, the Jeffersonian team must find out to whom the cremated remains at the funeral belong. The investigation gets complicated when the team finds there are three sets of remains in the urn.
The Jeffersonian team investigates the death of an art school dropout with Lupus, whose remains were found inside a log in a forest. The team learns about the victim's use of cannabis to treat her pain, and uncover details that contributed to her death.
NBA Basketball Los Angeles Lakers vs. Houston Rockets
Oliver returns to the mayor's office and faces one of his most pressing issues yet: the forced release of dozens of violent criminals prosecuted by Adrian Chase. Meanwhile, a crate is delivered to Oliver's office containing a mysterious corpse.